2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Bad Isoform
  6. Bad Modulator

Bad Modulator

Bad Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-182937
    FLC-8
    		Modulator
    FLC-8 is an orally active FLT3 inhibitor with IC50 values of 10.2 nM, 11.6 nM and 24.10 nM against human FLT3-WT, FLT3-G697R and FLT3-N676D, respectively. FLC-8 inhibits FLT3 autophosphorylation and downstream STAT5, AKT and ERK signaling pathways, and induces apoptosis in acute myeloid leukemia (AML) cells. FLC-8 exhibits potent antitumor activity in the MV4-11 xenograft model. FLC-8 can be used for the research of acute myeloid leukemia.